Deficient Gadd45β in rheumatoid arthritis: Enhanced synovitis through JNK signaling

OBJECTIVE: c-Jun-N-terminal kinase (JNK)-mediated cell signaling plays a critical role in metalloproteinase (MMP) expression and joint destruction in rheumatoid arthritis (RA). Gadd45β (growth arrest and DNA damage inducible gene), which is an NF-κB regulated gene, was recently identified as an endo...

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Bibliographic Details
Main Authors: Svensson, Camilla I., Inoue, Tomoyuki, Hammaker, Deepa, Fukushima, Akihisa, Papa, Salvatore, Franzoso, Guido, Schett, Georg, Corr, Maripat, Boyle, David L., Firestein, Gary S.
Format: Artigo
Language:Inglês
Published: 2009
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2858378/
https://ncbi.nlm.nih.gov/pubmed/19877043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.24887
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