Gadd45β promotes hepatocyte survival during liver regeneration in mice by modulating JNK signaling

In the liver, the JNK cascade is induced downstream of TNF receptors (TNFRs) in response to inflammatory, microbial, and toxic challenges. Sustained activation of JNK triggers programmed cell death (PCD), and hepatocyte survival during these challenges requires induction of the NF-κB pathway, which...

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Detalhes bibliográficos
Main Authors: Papa, Salvatore, Zazzeroni, Francesca, Fu, Yang-Xin, Bubici, Concetta, Alvarez, Kellean, Dean, Kathryn, Christiansen, Peter A., Anders, Robert A., Franzoso, Guido
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2008
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2276398/
https://ncbi.nlm.nih.gov/pubmed/18382767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI33913
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