Gadd45β promotes hepatocyte survival during liver regeneration in mice by modulating JNK signaling

In the liver, the JNK cascade is induced downstream of TNF receptors (TNFRs) in response to inflammatory, microbial, and toxic challenges. Sustained activation of JNK triggers programmed cell death (PCD), and hepatocyte survival during these challenges requires induction of the NF-κB pathway, which...

Full description

Saved in:
Bibliographic Details
Main Authors: Papa, Salvatore, Zazzeroni, Francesca, Fu, Yang-Xin, Bubici, Concetta, Alvarez, Kellean, Dean, Kathryn, Christiansen, Peter A., Anders, Robert A., Franzoso, Guido
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2008
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2276398/
https://ncbi.nlm.nih.gov/pubmed/18382767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI33913
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items