טוען...
Mechanistic Basis for Type 2 Long QT Syndrome Caused by KCNH2 Mutations that Disrupt Conserved Arginine Residue in the Voltage Sensor
KCNH2 encodes the Kv11.1 channel, which conducts the rapidly activating delayed rectifier K(+) current (I(Kr)) in the heart. KCNH2 mutations cause type 2 long QT syndrome (LQT2), which increases the risk for life-threatening ventricular arrhythmias. LQT2 mutations are predicted to prolong the cardia...
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| Main Authors: | , , , , , , , , , |
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| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
2013
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3706098/ https://ncbi.nlm.nih.gov/pubmed/23546015 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00232-013-9539-6 |
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