Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome

Calorie restriction (CR) extends lifespan in diverse species. Mitochondria play a key role in CR adaptation, however, the molecular details remain elusive. We developed and applied a quantitative mass spectrometry method to probe the liver mitochondrial acetyl-proteome during CR vs. control diet in...

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Autori principali: Hebert, Alexander S., Dittenhafer-Reed, Kristin E., Yu, Wei, Bailey, Derek J., Selen, Ebru Selin, Boersma, Melissa D., Carson, Joshua J., Tonelli, Marco, Balloon, Allison, Higbee, Alan J., Westphall, Michael S., Pagliarini, David J., Prolla, Tomas A., Assadi-Porter, Fariba, Roy, Sushmita, Denu, John M., Coon, Joshua J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3704155/
https://ncbi.nlm.nih.gov/pubmed/23201123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2012.10.024
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