Combined LFA-1 and costimulatory blockade prevents transplant rejection mediated by heterologous immune memory alloresponses

BACKGROUND: Recent evidence suggests that alloreactive memory T cells are generated by the process of heterologous immunity, whereby memory T cells arising in response to pathogen infection cross-react with donor antigens. Due to their diminished requirements for costimulation during recall, these p...

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Autores principales: Kitchens, William H., Haridas, Divya, Wagener, Maylene E., Song, Mingqing, Ford, Mandy L.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2012
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3703766/
https://ncbi.nlm.nih.gov/pubmed/22475765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/TP.0b013e31824e75d7
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