Direct single molecule measurement of TCR triggering by agonist pMHC in living primary T cells

T cells discriminate between self and foreign antigenic peptides, displayed on antigen presenting cell surfaces, via the TCR. While the molecular interactions between TCR and its ligands are well characterized in vitro, quantitative measurements of these interactions in living cells are required to...

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Hlavní autoři: O'Donoghue, Geoff P, Pielak, Rafal M, Smoligovets, Alexander A, Lin, Jenny J, Groves, Jay T
Médium: Artigo
Jazyk:Inglês
Vydáno: eLife Sciences Publications, Ltd 2013
Témata:
Biophysics and Structural Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3701909/
https://ncbi.nlm.nih.gov/pubmed/23840928
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.00778
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