Isolation and visualization of a structural trigger that uncouples TCR signaling from pMHC binding

TCR signaling strength generally correlates with peptide-MHC binding affinity; however, exceptions exist. We find high-affinity, yet non-stimulatory interactions occur with high frequency in the human T cell repertoire. Here, we studied human TCRs that are refractory to activation by pMHC ligands de...

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Publicado en:Cell
Autores principales: Sibener, Leah V., Fernandes, Ricardo A., Kolawole, Elizabeth M., Carbone, Catherine B., Liu, Fan, McAffee, Darren, Birnbaum, Michael E., Yang, Xinbo, Su, Laura F., Yu, Wong, Dong, Shen, Gee, Marvin H., Jude, Kevin M., Davis, Mark M., Groves, Jay T., Goddard, William A., Heath, James R., Evavold, Brian D., Vale, Ronald D., Garcia, K. Christopher
Formato: Artigo
Lenguaje:Inglês
Publicado: 2018
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6140336/
https://ncbi.nlm.nih.gov/pubmed/30053426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2018.06.017
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