Isolation and visualization of a structural trigger that uncouples TCR signaling from pMHC binding

TCR signaling strength generally correlates with peptide-MHC binding affinity; however, exceptions exist. We find high-affinity, yet non-stimulatory interactions occur with high frequency in the human T cell repertoire. Here, we studied human TCRs that are refractory to activation by pMHC ligands de...

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Bibliographic Details
Published in:Cell
Main Authors: Sibener, Leah V., Fernandes, Ricardo A., Kolawole, Elizabeth M., Carbone, Catherine B., Liu, Fan, McAffee, Darren, Birnbaum, Michael E., Yang, Xinbo, Su, Laura F., Yu, Wong, Dong, Shen, Gee, Marvin H., Jude, Kevin M., Davis, Mark M., Groves, Jay T., Goddard, William A., Heath, James R., Evavold, Brian D., Vale, Ronald D., Garcia, K. Christopher
Format: Artigo
Language:Inglês
Published: 2018
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6140336/
https://ncbi.nlm.nih.gov/pubmed/30053426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2018.06.017
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