Fine-Scale Patterns of Population Stratification Confound Rare Variant Association Tests

Advances in next-generation sequencing technology have enabled systematic exploration of the contribution of rare variation to Mendelian and complex diseases. Although it is well known that population stratification can generate spurious associations with common alleles, its impact on rare variant a...

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Bibliographic Details
Main Authors:	O’Connor, Timothy D., Kiezun, Adam, Bamshad, Michael, Rich, Stephen S., Smith, Joshua D., Turner, Emily, Leal, Suzanne M., Akey, Joshua M.
Format:	Artigo
Language:	Inglês
Published:	Public Library of Science 2013
Subjects:	Research Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC3701690/ https://ncbi.nlm.nih.gov/pubmed/23861739 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0065834
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Fine-Scale Patterns of Population Stratification Confound Rare Variant Association Tests

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