Fine-Scale Patterns of Population Stratification Confound Rare Variant Association Tests

Advances in next-generation sequencing technology have enabled systematic exploration of the contribution of rare variation to Mendelian and complex diseases. Although it is well known that population stratification can generate spurious associations with common alleles, its impact on rare variant a...

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Autores principales: O’Connor, Timothy D., Kiezun, Adam, Bamshad, Michael, Rich, Stephen S., Smith, Joshua D., Turner, Emily, Leal, Suzanne M., Akey, Joshua M.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3701690/
https://ncbi.nlm.nih.gov/pubmed/23861739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0065834
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