A Huntingtin Peptide Inhibits PolyQ-Huntingtin Associated Defects

BACKGROUND: Huntington’s disease (HD) is caused by the abnormal expansion of the polyglutamine tract in the human Huntingtin protein (polyQ-hHtt). Although this mutation behaves dominantly, huntingtin loss of function also contributes to HD pathogenesis. Indeed, wild-type Huntingtin plays a protecti...

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Main Authors: Arribat, Yoan, Bonneaud, Nathalie, Talmat-Amar, Yasmina, Layalle, Sophie, Parmentier, Marie-Laure, Maschat, Florence
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2013
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3701666/
https://ncbi.nlm.nih.gov/pubmed/23861941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0068775
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