DNA Methylation of Alternative Promoters Directs Tissue Specific Expression of Epac2 Isoforms

Epac 1 and Epac 2 (Epac1/2; exchange factors directly activated by cAMP) are multidomain proteins that mediate cellular responses upon activation by the signaling molecule cAMP. Epac1 is ubiquitously expressed, whereas Epac2 exhibits a restricted expression pattern. The gene encoding Epac2 gives ris...

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Detalhes bibliográficos
Main Authors: Hoivik, Erling A., Witsoe, Solveig L., Bergheim, Inger R., Xu, Yunjian, Jakobsson, Ida, Tengholm, Anders, Doskeland, Stein Ove, Bakke, Marit
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3701594/
https://ncbi.nlm.nih.gov/pubmed/23861833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0067925
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