Epac1-deficient mice have bleeding phenotype and thrombocytes with decreased GPIbβ expression

Epac1 (Exchange protein directly activated by cAMP 1) limits fluid loss from the circulation by tightening the endothelial barrier. We show here that Epac1(−/−) mice, but not Epac2(−/−) mice, have prolonged bleeding time, suggesting that Epac1 may limit fluid loss also by restraining bleeding. The E...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Nygaard, Gyrid, Herfindal, Lars, Asrud, Kathrine S., Bjørnstad, Ronja, Kopperud, Reidun K., Oveland, Eystein, Berven, Frode S., Myhren, Lene, Hoivik, Erling A., Lunde, Turid Helen Felli, Bakke, Marit, Døskeland, Stein O., Selheim, Frode
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5562764/
https://ncbi.nlm.nih.gov/pubmed/28821815
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-08975-y
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