Fusion pore regulation by cAMP/Epac2 controls cargo release during insulin exocytosis

Regulated exocytosis establishes a narrow fusion pore as initial aqueous connection to the extracellular space, through which small transmitter molecules such as ATP can exit. Co-release of polypeptides and hormones like insulin requires further expansion of the pore. There is evidence that pore exp...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Guček, Alenka, Gandasi, Nikhil R, Omar-Hmeadi, Muhmmad, Bakke, Marit, Døskeland, Stein O, Tengholm, Anders, Barg, Sebastian
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2019
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6557626/
https://ncbi.nlm.nih.gov/pubmed/31099751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.41711
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