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Paracrine control of α-cell glucagon exocytosis is compromised in human type-2 diabetes
Glucagon is released from pancreatic α-cells to activate pathways that raise blood glucose. Its secretion is regulated by α-cell-intrinsic glucose sensing and paracrine control through insulin and somatostatin. To understand the inadequately high glucagon levels that contribute to hyperglycemia in t...
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| Опубликовано в: : | Nat Commun |
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| Главные авторы: | , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Nature Publishing Group UK
2020
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7171169/ https://ncbi.nlm.nih.gov/pubmed/32312960 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-15717-8 |
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