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Stage-specific regulation of reprogramming to iPSCs by Wnt signaling and Tcf proteins

Wnt signaling is intrinsic to mouse embryonic stem cell self-renewal. Therefore it is surprising that reprogramming of somatic cells to induced pluripotent stem cells (iPSCs) is not strongly enhanced by Wnt signaling. Here, we demonstrate that active Wnt signaling inhibits the early stage of reprogr...

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Bibliografske podrobnosti
Main Authors: Ho, Ritchie, Papp, Bernadett, Hoffman, Jackson A., Merrill, Bradley J., Plath, Kathrin
Format: Artigo
Jezik:Inglês
Izdano: 2013
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3700671/
https://ncbi.nlm.nih.gov/pubmed/23791530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2013.05.015
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