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Stage-specific regulation of reprogramming to iPSCs by Wnt signaling and Tcf proteins
Wnt signaling is intrinsic to mouse embryonic stem cell self-renewal. Therefore it is surprising that reprogramming of somatic cells to induced pluripotent stem cells (iPSCs) is not strongly enhanced by Wnt signaling. Here, we demonstrate that active Wnt signaling inhibits the early stage of reprogr...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3700671/ https://ncbi.nlm.nih.gov/pubmed/23791530 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2013.05.015 |
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