Ligand-Binding Architecture of Human CB2 Cannabinoid Receptor: Evidence for Receptor Subtype-Specific Binding Motif and Modeling GPCR Activation

The extensive physiological influence of transmission through the CB2 cannabinoid receptor makes this G protein-coupled receptor (GPCR) a promising therapeutic target for treating neuropathic pain, inflammation, and immune disorders. However, there is little direct structural information pertaining...

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Detalhes bibliográficos
Main Authors: Pei, Ying, Mercier, Richard W., Anday, Jenine K., Thakur, Ganesh A., Zvonok, Alexander M., Hurst, Dow, Reggio, Patricia H., Janero, David R., Makriyannis, Alexandros
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3700404/
https://ncbi.nlm.nih.gov/pubmed/19022181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2008.10.011
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