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Leveraging allostery to improve G protein-coupled receptor (GPCR)-directed therapeutics: cannabinoid receptor 1 as discovery target
INTRODUCTION: Allosteric modulators of G-protein coupled receptors (GPCRs) hold the promise of improved pharmacology and safety over typical orthosteric GPCR ligands. These features are particularly relevant to the cannabinoid receptor 1 (CB1R) GPCR, since typical orthosteric CB1R ligands are associ...
保存先:
| 出版年: | Expert Opin Drug Discov |
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| 主要な著者: | , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2016
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6108444/ https://ncbi.nlm.nih.gov/pubmed/27712124 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/17460441.2016.1245289 |
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