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Leveraging allostery to improve G protein-coupled receptor (GPCR)-directed therapeutics: cannabinoid receptor 1 as discovery target

INTRODUCTION: Allosteric modulators of G-protein coupled receptors (GPCRs) hold the promise of improved pharmacology and safety over typical orthosteric GPCR ligands. These features are particularly relevant to the cannabinoid receptor 1 (CB1R) GPCR, since typical orthosteric CB1R ligands are associ...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Expert Opin Drug Discov
Hauptverfasser: Janero, David R., Thakur, Ganesh A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6108444/
https://ncbi.nlm.nih.gov/pubmed/27712124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/17460441.2016.1245289
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