Increased Frequency and Suppression by Regulatory T Cells in Patients with Acute Myelogenous Leukemia

PURPOSE: Regulatory CD4(+)CD25(high)Foxp3(+) T cells (Treg) control peripheral immune tolerance. Patients with cancer, including those with hematologic malignancies, have elevated numbers of Treg in the peripheral circulation and in tumor tissues. However, mechanisms of suppression and clinical sign...

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Autori principali: Szczepanski, Miroslaw J., Szajnik, Marta, Czystowska, Malgorzata, Mandapathil, Magis, Strauss, Laura, Welsh, Ann, Foon, Kenneth A., Whiteside, Theresa L., Boyiadzis, Michael
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3700356/
https://ncbi.nlm.nih.gov/pubmed/19417016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-08-3010
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