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Differential Responses of Human Regulatory T Cells (Treg) and Effector T Cells to Rapamycin
BACKGROUND: The immunosuppressive drug rapamycin (RAPA) promotes the expansion of CD4(+) CD25(high)Foxp3(+) regulatory T cells via mechanisms that remain unknown. Here, we studied expansion, IL-2R-γ chain signaling, survival pathways and resistance to apoptosis in human Treg responding to RAPA. METH...
Gorde:
| Egile Nagusiak: | , , , , |
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| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
Public Library of Science
2009
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2694984/ https://ncbi.nlm.nih.gov/pubmed/19543393 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0005994 |
| Etiketak: |
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