Structure-Activity Relationships of Lipopolysaccharide Sequestration in N-Alkylpolyamines

We have previously shown that simple N-acyl or N-alkyl polyamines bind to and sequester Gram-negative bacterial lipopolysaccharide, affording protection against lethality in animal models of endotoxicosis. Several iterative design-and-test cycles of SAR studies, including high-throughput screens, ha...

Full description

Saved in:
Bibliographic Details
Main Authors: Shrestha, Anurupa, Sil, Diptesh, Malladi, Subbalakshmi S., Warshakoon, Hemamali J., David, Sunil A.
Format: Artigo
Language:Inglês
Published: 2009
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3699868/
https://ncbi.nlm.nih.gov/pubmed/19332373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2009.03.055
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items