Bound To Shock: Protection from Lethal Endotoxemic Shock by a Novel, Nontoxic, Alkylpolyamine Lipopolysaccharide Sequestrant

Lipopolysaccharide (LPS), or endotoxin, a structural component of gram-negative bacterial outer membranes, plays a key role in the pathogenesis of septic shock, a syndrome of severe systemic inflammation which leads to multiple-system organ failure. Despite advances in antimicrobial chemotherapy, se...

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Autori principali: Sil, Diptesh, Shrestha, Anurupa, Kimbrell, Matthew R., Nguyen, Thuan B., Adisechan, Ashok K., Balakrishna, Rajalakshmi, Abbo, Benjamin G., Malladi, Subbalakshmi, Miller, Kelly A., Short, Shannon, Cromer, Jens R., Arora, Shravan, Datta, Apurba, David, Sunil A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2007
Soggetti:
Experimental Therapeutics
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1932507/
https://ncbi.nlm.nih.gov/pubmed/17548488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00200-07
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