Structure-Activity Relationships of Lipopolysaccharide Sequestration in N-Alkylpolyamines

We have previously shown that simple N-acyl or N-alkyl polyamines bind to and sequester Gram-negative bacterial lipopolysaccharide, affording protection against lethality in animal models of endotoxicosis. Several iterative design-and-test cycles of SAR studies, including high-throughput screens, ha...

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Main Authors: Shrestha, Anurupa, Sil, Diptesh, Malladi, Subbalakshmi S., Warshakoon, Hemamali J., David, Sunil A.
Formato: Artigo
Idioma:Inglês
Publicado: 2009
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3699868/
https://ncbi.nlm.nih.gov/pubmed/19332373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2009.03.055
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