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Extracellular Protons Inhibit Charge Immobilization in the Cardiac Voltage-Gated Sodium Channel
Low pH depolarizes the voltage-dependence of cardiac voltage-gated sodium (Na(V)1.5) channel activation and fast inactivation and destabilizes the fast-inactivated state. The molecular basis for these changes in protein behavior has not been reported. We hypothesized that changes in the kinetics of...
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| 主要な著者: | , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
The Biophysical Society
2013
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3699744/ https://ncbi.nlm.nih.gov/pubmed/23823228 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2013.04.022 |
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