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Extracellular Protons Inhibit Charge Immobilization in the Cardiac Voltage-Gated Sodium Channel

Low pH depolarizes the voltage-dependence of cardiac voltage-gated sodium (Na(V)1.5) channel activation and fast inactivation and destabilizes the fast-inactivated state. The molecular basis for these changes in protein behavior has not been reported. We hypothesized that changes in the kinetics of...

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Détails bibliographiques
Auteurs principaux: Jones, D.K., Claydon, T.W., Ruben, P.C.
Format: Artigo
Langue:Inglês
Publié: The Biophysical Society 2013
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3699744/
https://ncbi.nlm.nih.gov/pubmed/23823228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2013.04.022
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