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Changes in Protein Architecture and Sub-Picosecond Protein Dynamics Impact the Reaction Catalyzed by Lactate Dehydrogenase
We have previously established the importance of a promoting vibration, a sub-picosecond protein motion that propagates through a specific axis of residues, in the reaction coordinate of lactate dehydrogenase (LDH). To test the effect that perturbation of this motion would have on the enzymatic reac...
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| Autori principali: | , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2013
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3695017/ https://ncbi.nlm.nih.gov/pubmed/23441954 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jp400376h |
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