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Ligand Binding and Protein Dynamics in Lactate Dehydrogenase
Recent experimental studies suggest that lactate dehydrogenase (LDH) binds its substrate via the formation of a LDH/NADH·substrate encounter complex through a select-fit mechanism, whereby only a minority population of LDH/NADH is binding-competent. In this study, we perform molecular dynamics calcu...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
The Biophysical Society
2007
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1948035/ https://ncbi.nlm.nih.gov/pubmed/17483170 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.107.106146 |
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