Ligand Binding and Protein Dynamics in Lactate Dehydrogenase

Recent experimental studies suggest that lactate dehydrogenase (LDH) binds its substrate via the formation of a LDH/NADH·substrate encounter complex through a select-fit mechanism, whereby only a minority population of LDH/NADH is binding-competent. In this study, we perform molecular dynamics calcu...

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Hauptverfasser: Pineda, J. R. Exequiel T., Callender, Robert, Schwartz, Steven D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Biophysical Society 2007
Schlagworte:
Biophysical Theory and Modeling
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1948035/
https://ncbi.nlm.nih.gov/pubmed/17483170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.107.106146
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