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Changes in Protein Architecture and Sub-Picosecond Protein Dynamics Impact the Reaction Catalyzed by Lactate Dehydrogenase

We have previously established the importance of a promoting vibration, a sub-picosecond protein motion that propagates through a specific axis of residues, in the reaction coordinate of lactate dehydrogenase (LDH). To test the effect that perturbation of this motion would have on the enzymatic reac...

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Hlavní autoři: Masterson, Jean E., Schwartz, Steven D.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3695017/
https://ncbi.nlm.nih.gov/pubmed/23441954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jp400376h
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