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PUMA: A Unified Framework for Penalized Multiple Regression Analysis of GWAS Data

Penalized Multiple Regression (PMR) can be used to discover novel disease associations in GWAS datasets. In practice, proposed PMR methods have not been able to identify well-supported associations in GWAS that are undetectable by standard association tests and thus these methods are not widely appl...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Hoffman, Gabriel E., Logsdon, Benjamin A., Mezey, Jason G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2013
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3694815/
https://ncbi.nlm.nih.gov/pubmed/23825936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1003101
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