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PUMA: A Unified Framework for Penalized Multiple Regression Analysis of GWAS Data

Penalized Multiple Regression (PMR) can be used to discover novel disease associations in GWAS datasets. In practice, proposed PMR methods have not been able to identify well-supported associations in GWAS that are undetectable by standard association tests and thus these methods are not widely appl...

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Detalhes bibliográficos
Main Authors: Hoffman, Gabriel E., Logsdon, Benjamin A., Mezey, Jason G.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3694815/
https://ncbi.nlm.nih.gov/pubmed/23825936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1003101
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