STAT3 plays a critical role in KRAS-induced pancreatic tumorigenesis

The STAT3 transcription factor is an important regulator of stem cell self-renewal, cancer cell survival, and inflammation. In the pancreas, STAT3 is dispensable for normal development whereas the majority of pancreatic ductal adenocarcinomas (PDAC) show constitutive activation of STAT3, suggesting...

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Autori principali: Corcoran, Ryan B., Contino, Gianmarco, Deshpande, Vikram, Tzatsos, Alexandros, Conrad, Claudius, Benes, Cyril H., Settleman, Jeffrey, Engelman, Jeffrey A., Bardeesy, Nabeel
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3693754/
https://ncbi.nlm.nih.gov/pubmed/21586612
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-11-0908
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