The Toll-like Receptor 9 Ligand, CpG Oligodeoxynucleotide, Attenuates Cardiac Dysfunction in Polymicrobial Sepsis, Involving Activation of Both Phosphoinositide 3 Kinase/Akt and Extracellular-Signal-Related Kinase Signaling

Background. Toll-like receptors (TLRs) play a role in the pathophysiology of sepsis and multiple organ failure. This study examined the effect of CpG oligodeoxynucleotide (CpG-ODN), the TLR9 ligand, on polymicrobial sepsis–induced cardiac dysfunction. Methods. Male C57BL/6 mice were treated with CpG...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Gao, Ming, Ha, Tuanzhu, Zhang, Xia, Wang, Xiaohui, Liu, Li, Kalbfleisch, John, Singh, Krishna, Williams, David, Li, Chuanfu
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Oxford University Press 2013
Aiheet:
Major Articles and Brief Reports
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3693590/
https://ncbi.nlm.nih.gov/pubmed/23359590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jit036
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