HSP90 Inhibitors, Geldanamycin and Radicicol, Enhance Fisetin-Induced Cytotoxicity via Induction of Apoptosis in Human Colonic Cancer Cells

We revealed the cytotoxic effect of the flavonoid, fisetin (FIS), on human COLO205 colon cancer cells in the presence and absence of the HSP90 inhibitors, geldanamycin (GA) and radicicol (RAD). Compared to FIS treatment alone of COLO205 cells, GA and RAD significantly enhanced FIS-induced cytotoxici...

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Bibliografske podrobnosti
Main Authors: Wu, Ming-Shun, Lien, Gi-Shih, Shen, Shing-Chuan, Yang, Liang-Yo, Chen, Yen-Chou
Format: Artigo
Jezik:Inglês
Izdano: Hindawi Publishing Corporation 2013
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3693119/
https://ncbi.nlm.nih.gov/pubmed/23840275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2013/987612
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