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Role of oxidative stress in Geldanamycin-induced cytotoxicity and disruption of Hsp90 signaling complex
Heat shock protein 90 (Hsp90) is a chaperone protein regulating PC-12 cell survival by binding and stabilizing Akt, Raf-1, and Cdc37. Hsp90 inhibitor Geldanamycin (GA) cytotoxicity has been attributed to disruption of Hsp90 binding, and the contribution of oxidative stress generated by its quinone g...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2767391/ https://ncbi.nlm.nih.gov/pubmed/19703551 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2009.08.012 |
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