Antibiotic radicicol binds to the N-terminal domain of Hsp90 and shares important biologic activities with geldanamycin

The molecular chaperone Hsp90 plays an essential role in the folding and function of important cellular proteins including steroid hormone receptors, protein kinases and proteins controlling the cell cycle and apoptosis. A 15 Å deep pocket region in the N-terminal domain of Hsp90 serves as an ATP/AD...

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Bibliografski detalji
Glavni autori: Schulte, Theodor W., Akinaga, Shiro, Soga, Shiro, Sullivan, William, Stensgard, Bridget, Toft, David, Neckers, Leonard M.
Format: Artigo
Jezik:Inglês
Izdano: Cell Stress Society International 1998
Teme:
Original Articles
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC312953/
https://ncbi.nlm.nih.gov/pubmed/9672245
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