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UBE2G1 governs the destruction of cereblon neomorphic substrates

The cereblon modulating agents (CMs) including lenalidomide, pomalidomide and CC-220 repurpose the Cul4-RBX1-DDB1-CRBN (CRL4CRBN) E3 ubiquitin ligase complex to induce the degradation of specific neomorphic substrates via polyubiquitination in conjunction with E2 ubiquitin-conjugating enzymes, which...

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Autors principals: Gang Lu, Stephanie Weng, Mary Matyskiela, Xinde Zheng, Wei Fang, Scott Wood, Christine Surka, Reina Mizukoshi, Chin-Chun Lu, Derek Mendy, In Sock Jang, Kai Wang, Mathieu Marella, Suzana Couto, Brian Cathers, James Carmichael, Philip Chamberlain, Mark Rolfe
Format: Artigo
Idioma:Inglês
Publicat: eLife Sciences Publications Ltd 2018-09-01
Col·lecció:eLife
Matèries:
ubiquitination
cereblon
immunomodulatory drugs
cereblon modulating agents
PROTAC
Accés en línia:https://elifesciences.org/articles/40958
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