Next Generation Sequencing of Prostate Cancer from a Patient Identifies a Deficiency of Methylthioadenosine Phosphorylase (MTAP), an Exploitable Tumor Target

Castrate resistant prostate cancer (CRPC) and neuroendocrine carcinoma of the prostate are invariably fatal diseases for which only palliative therapies exist. As part of a prostate tumour sequencing program, a patient tumour was analyzed using Illumina genome sequencing and a matched renal capsule...

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Detalhes bibliográficos
Main Authors: Collins, Colin C, Volik, Stanislav V, Lapuk, Anna V, Wang, Yuwei, Gout, Peter W, Wu, Chunxiao, Xue, Hui, Cheng, Hongwei, Haegert, Anne, Bell, Robert H, Brahmbhatt, Sonal, Anderson, Shawn, Fazli, Ladan, Hurtado-Coll, Antonio, Rubin, Mark A., Demichelis, Francesca, Beltran, Himisha, Hirst, Martin, Marra, Marco, Maher, Christopher A., Chinnaiyan, Arul M., Gleave, Martin, Bertino, Joseph R., Lubin, Martin, Wang, Yuzhuo
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3691697/
https://ncbi.nlm.nih.gov/pubmed/22252602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-11-0826
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