Synthesis and in vivo evaluation of the putative breast cancer resistance protein inhibitor [(11)C]methyl 4-((4-(2-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-2-yl)ethyl)phenyl)amino-carbonyl)-2-(quinoline-2-carbonylamino)benzoate

INTRODUCTION: The multidrug efflux transporter breast cancer resistance protein (BCRP) is highly expressed in the blood-brain barrier (BBB), where it limits brain entry of a broad range of endogenous and exogenous substrates. Methyl 4-((4-(2-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-2-yl)ethyl)ph...

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Autori principali: Mairinger, Severin, Langer, Oliver, Kuntner, Claudia, Wanek, Thomas, Bankstahl, Jens P., Bankstahl, Marion, Stanek, Johann, Dörner, Bernd, Bauer, Florian, Baumgartner, Christoph, Löscher, Wolfgang, Erker, Thomas, Müller, Markus
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3690702/
https://ncbi.nlm.nih.gov/pubmed/20610168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nucmedbio.2010.02.008
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