Radiosynthesis and in vivo evaluation of 1-[(18)F]fluoroelacridar as a positron emission tomography tracer for P-glycoprotein and breast cancer resistance protein

Aim of this study was to label the potent dual P-glycoprotein (Pgp) and breast cancer resistance protein (BCRP) inhibitor elacridar (1) with (18)F to provide a positron emission tomography (PET) radiotracer to visualize Pgp and BCRP. A series of new 1- and 2-halogen- and nitro-substituted derivative...

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Main Authors: Dörner, Bernd, Kuntner, Claudia, Bankstahl, Jens P., Wanek, Thomas, Bankstahl, Marion, Stanek, Johann, Müllauer, Julia, Bauer, Florian, Mairinger, Severin, Löscher, Wolfgang, Miller, Donald W., Chiba, Peter, Müller, Markus, Erker, Thomas, Langer, Oliver
Format: Artigo
Sprog:Inglês
Udgivet: 2011
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3690701/
https://ncbi.nlm.nih.gov/pubmed/21419632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2011.02.039
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