A Notch1 Ectodomain Construct Inhibits Endothelial Notch Signaling, Tumor Growth, and Angiogenesis

Notch signaling is required for vascular development and tumor angiogenesis. Although inhibition of the Notch ligand Delta-like 4 can restrict tumor growth and disrupt neo-vasculature, the effect of inhibiting Notch receptor function on angiogenesis has yet to be defined. In this study, we generated...

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Main Authors: Funahashi, Yasuhiro, Hernandez, Sonia L., Das, Indranil, Ahn, Audrey, Huang, Jianzhong, Vorontchikhina, Marina, Sharma, Anshula, Kanamaru, Emi, Borisenko, Valeriya, DeSilva, Dinuka M., Suzuki, Akihiko, Wang, Xing, Shawber, Carrie J., Kandel, Jessica J., Yamashiro, Darrell J., Kitajewski, Jan
Formato: Artigo
Idioma:Inglês
Publicado: 2008
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3690602/
https://ncbi.nlm.nih.gov/pubmed/18559519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-07-6499
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