Notch regulates the angiogenic response via induction of VEGFR-1

Notch is a critical regulator of angiogenesis and arterial specification. We show that ectopic expression of activated Notch1 induces endothelial morphogenesis in human umbilical vein endothelial cells (HUVEC) in a VEGFR-1-dependent manner. Notch1-mediated upregulation of VEGFR-1 in HUVEC increased...

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Detalhes bibliográficos
Main Authors: Funahashi, Yasuhiro, Shawber, Carrie J, Vorontchikhina, Marina, Sharma, Anshula, Outtz, Hasina H, Kitajewski, Jan
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2010
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2828996/
https://ncbi.nlm.nih.gov/pubmed/20298529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2040-2384-2-3
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