Notch alters VEGF responsiveness in human and murine endothelial cells by direct regulation of VEGFR-3 expression

The Notch family of cell surface receptors and its ligands are highly conserved proteins that regulate cell fate determination, including those involved in mammalian vascular development. We report that Notch induces VEGFR-3 expression in vitro in human endothelial cells and in vivo in mice. In vitr...

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Główni autorzy: Shawber, Carrie J., Funahashi, Yasuhiro, Francisco, Esther, Vorontchikhina, Marina, Kitamura, Yukari, Stowell, Stephanie A., Borisenko, Valeriya, Feirt, Nikki, Podgrabinska, Simona, Shiraishi, Kazuko, Chawengsaksophak, Kallayanee, Rossant, Janet, Accili, Domenico, Skobe, Mihaela, Kitajewski, Jan
Format: Artigo
Język:Inglês
Wydane: American Society for Clinical Investigation 2007
Hasła przedmiotowe:
Research Article
Dostęp online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2030453/
https://ncbi.nlm.nih.gov/pubmed/17948123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI24311
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