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Notch alters VEGF responsiveness in human and murine endothelial cells by direct regulation of VEGFR-3 expression
The Notch family of cell surface receptors and its ligands are highly conserved proteins that regulate cell fate determination, including those involved in mammalian vascular development. We report that Notch induces VEGFR-3 expression in vitro in human endothelial cells and in vivo in mice. In vitr...
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| Главные авторы: | , , , , , , , , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Society for Clinical Investigation
2007
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2030453/ https://ncbi.nlm.nih.gov/pubmed/17948123 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI24311 |
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