Notch alters VEGF responsiveness in human and murine endothelial cells by direct regulation of VEGFR-3 expression

The Notch family of cell surface receptors and its ligands are highly conserved proteins that regulate cell fate determination, including those involved in mammalian vascular development. We report that Notch induces VEGFR-3 expression in vitro in human endothelial cells and in vivo in mice. In vitr...

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Главные авторы: Shawber, Carrie J., Funahashi, Yasuhiro, Francisco, Esther, Vorontchikhina, Marina, Kitamura, Yukari, Stowell, Stephanie A., Borisenko, Valeriya, Feirt, Nikki, Podgrabinska, Simona, Shiraishi, Kazuko, Chawengsaksophak, Kallayanee, Rossant, Janet, Accili, Domenico, Skobe, Mihaela, Kitajewski, Jan
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Clinical Investigation 2007
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2030453/
https://ncbi.nlm.nih.gov/pubmed/17948123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI24311
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