Notch alters VEGF responsiveness in human and murine endothelial cells by direct regulation of VEGFR-3 expression

The Notch family of cell surface receptors and its ligands are highly conserved proteins that regulate cell fate determination, including those involved in mammalian vascular development. We report that Notch induces VEGFR-3 expression in vitro in human endothelial cells and in vivo in mice. In vitr...

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Hlavní autoři: Shawber, Carrie J., Funahashi, Yasuhiro, Francisco, Esther, Vorontchikhina, Marina, Kitamura, Yukari, Stowell, Stephanie A., Borisenko, Valeriya, Feirt, Nikki, Podgrabinska, Simona, Shiraishi, Kazuko, Chawengsaksophak, Kallayanee, Rossant, Janet, Accili, Domenico, Skobe, Mihaela, Kitajewski, Jan
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2007
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2030453/
https://ncbi.nlm.nih.gov/pubmed/17948123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI24311
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