Notch alters VEGF responsiveness in human and murine endothelial cells by direct regulation of VEGFR-3 expression

The Notch family of cell surface receptors and its ligands are highly conserved proteins that regulate cell fate determination, including those involved in mammalian vascular development. We report that Notch induces VEGFR-3 expression in vitro in human endothelial cells and in vivo in mice. In vitr...

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主要な著者: Shawber, Carrie J., Funahashi, Yasuhiro, Francisco, Esther, Vorontchikhina, Marina, Kitamura, Yukari, Stowell, Stephanie A., Borisenko, Valeriya, Feirt, Nikki, Podgrabinska, Simona, Shiraishi, Kazuko, Chawengsaksophak, Kallayanee, Rossant, Janet, Accili, Domenico, Skobe, Mihaela, Kitajewski, Jan
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Clinical Investigation 2007
主題:
Research Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2030453/
https://ncbi.nlm.nih.gov/pubmed/17948123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI24311
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