Impaired angiogenesis and altered Notch signaling in mice overexpressing endothelial Egfl7

Epidermal growth factor-like domain 7 (Egfl7) is important for regulating tubulogenesis in zebrafish, but its role in mammals remains unresolved. We show here that endothelial overexpression of Egfl7 in transgenic mice leads to partial lethality, hemorrhaging, and altered cardiac morphogenesis. Thes...

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Autori principali: Nichol, Donna, Shawber, Carrie, Fitch, Michael J., Bambino, Kathryn, Sharma, Anshula, Kitajewski, Jan, Stuhlmann, Heidi
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2010
Soggetti:
Vascular Biology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3031397/
https://ncbi.nlm.nih.gov/pubmed/20947685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-03-274860
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