Impaired angiogenesis and altered Notch signaling in mice overexpressing endothelial Egfl7

Epidermal growth factor-like domain 7 (Egfl7) is important for regulating tubulogenesis in zebrafish, but its role in mammals remains unresolved. We show here that endothelial overexpression of Egfl7 in transgenic mice leads to partial lethality, hemorrhaging, and altered cardiac morphogenesis. Thes...

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Bibliographic Details
Main Authors: Nichol, Donna, Shawber, Carrie, Fitch, Michael J., Bambino, Kathryn, Sharma, Anshula, Kitajewski, Jan, Stuhlmann, Heidi
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2010
Subjects:
Vascular Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3031397/
https://ncbi.nlm.nih.gov/pubmed/20947685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-03-274860
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