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Impaired angiogenesis and altered Notch signaling in mice overexpressing endothelial Egfl7
Epidermal growth factor-like domain 7 (Egfl7) is important for regulating tubulogenesis in zebrafish, but its role in mammals remains unresolved. We show here that endothelial overexpression of Egfl7 in transgenic mice leads to partial lethality, hemorrhaging, and altered cardiac morphogenesis. Thes...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society of Hematology
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3031397/ https://ncbi.nlm.nih.gov/pubmed/20947685 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-03-274860 |
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