Grapefruit juice markedly increases the plasma concentrations and antiplatelet effects of ticagrelor in healthy subjects

AIM: This study examined the effects of grapefruit juice on the new P2Y(12) inhibitor ticagrelor, which is a substrate of CYP3A4 and P-glycoprotein. METHODS: In a randomized crossover study, 10 healthy volunteers ingested 200 ml of grapefruit juice or water thrice daily for 4 days. On day 3, they in...

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Autors principals: Holmberg, Mikko T, Tornio, Aleksi, Joutsi-Korhonen, Lotta, Neuvonen, Mikko, Neuvonen, Pertti J, Lassila, Riitta, Niemi, Mikko, Backman, Janne T
Format: Artigo
Idioma:Inglês
Publicat: Blackwell Science Inc 2013
Matèries:
Drug Interactions
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3690107/
https://ncbi.nlm.nih.gov/pubmed/23126367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12026
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