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Effect of carboxylesterase 1 c.428G > A single nucleotide variation on the pharmacokinetics of quinapril and enalapril

AIM: The aim of the present study was to investigate the effects of the carboxylesterase 1 (CES1) c.428G > A (p.G143E, rs71647871) single nucleotide variation (SNV) on the pharmacokinetics of quinapril and enalapril in a prospective genotype panel study in healthy volunteers. METHODS: In a fixed-...

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Detalhes bibliográficos
Publicado no:Br J Clin Pharmacol
Main Authors: Tarkiainen, E Katriina, Tornio, Aleksi, Holmberg, Mikko T, Launiainen, Terhi, Neuvonen, Pertti J, Backman, Janne T, Niemi, Mikko
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley & Sons, Ltd 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4631185/
https://ncbi.nlm.nih.gov/pubmed/25919042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12667
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