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Enzymatic Detoxication, Conformational Selection, and the Role of Molten Globule Active Sites

The role of conformational ensembles in enzymatic reactions remains unclear. Discussion concerning “induced fit” versus “conformational selection” has, however, ignored detoxication enzymes, which exhibit catalytic promiscuity. These enzymes dominate drug metabolism and determine drug-drug interacti...

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Bibliografski detalji
Glavni autori: Honaker, Matthew T., Acchione, Mauro, Zhang, Wei, Mannervik, Bengt, Atkins, William M.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2013
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3689999/
https://ncbi.nlm.nih.gov/pubmed/23649628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.445767
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