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Enzymatic Detoxication, Conformational Selection, and the Role of Molten Globule Active Sites
The role of conformational ensembles in enzymatic reactions remains unclear. Discussion concerning “induced fit” versus “conformational selection” has, however, ignored detoxication enzymes, which exhibit catalytic promiscuity. These enzymes dominate drug metabolism and determine drug-drug interacti...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3689999/ https://ncbi.nlm.nih.gov/pubmed/23649628 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.445767 |
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