Enzymatic Detoxication, Conformational Selection, and the Role of Molten Globule Active Sites

The role of conformational ensembles in enzymatic reactions remains unclear. Discussion concerning “induced fit” versus “conformational selection” has, however, ignored detoxication enzymes, which exhibit catalytic promiscuity. These enzymes dominate drug metabolism and determine drug-drug interacti...

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Bibliographic Details
Main Authors: Honaker, Matthew T., Acchione, Mauro, Zhang, Wei, Mannervik, Bengt, Atkins, William M.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2013
Subjects:
Enzymology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3689999/
https://ncbi.nlm.nih.gov/pubmed/23649628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.445767
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