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Ensemble Perspective for Catalytic Promiscuity: CALORIMETRIC ANALYSIS OF THE ACTIVE SITE CONFORMATIONAL LANDSCAPE OF A DETOXIFICATION ENZYME
Enzymological paradigms have shifted recently to acknowledge the biological importance of catalytic promiscuity. However, catalytic promiscuity is a poorly understood property, and no thermodynamic treatment has described the conformational landscape of promiscuous versus substrate-specific enzymes....
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Biochemistry and Molecular Biology
2011
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3234982/ https://ncbi.nlm.nih.gov/pubmed/22002059 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.304386 |
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